Research Article|Articles in Press

The effect of Centella Asiatica cream on scar development in patients who underwent open carpal tunnel release surgery

  • Mustafa Balevi
    Corresponding author. Neurosurgery expert. Department of Neurosurgery, Konya Numune State Hospital, Ferhuniye Mah. Hastane Cd. No:22 Selçuklu Konya /Turkey 42060, Telephone no. +90–3323252090, Fax: +903 3 22356786
    Neurosurgery expert. Department of Neurosurgery, Konya Numune State Hospital, Konya, Turkey
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  • Ali Balevi
    Department of Dermatology, Istanbul Medipol University, School of Medicine, Turkey
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Published:March 12, 2023DOI:



      To evaluate the efficacy of the Centella asiatica extract in a cream preparation for the prevention of scar tenderness formation in patients who underwent conventional open carpal tunnel release (CTR) surgery.

      Material and Methods

      A total of 280 patients with carpal tunnel syndrome who underwent CTR surgery were individually randomized into the intervention (n = 140) and control (n = 140) groups. In the intervention group, a petroleum cream mixture consisting of 1% Centella asiatica extract was applied to the patients’ wrist for 6 months after the sutures were removed. In the control group, no intervention was applied. The Vancouver Scar Scale (VSS), Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) functional score, and Visual Analog Scale (VAS) satisfaction scores were assessed preoperatively and postoperatively. Follow-up evaluations were scheduled at 1, 3 and 6 months after CTR surgery.


      The overall VSS score of the intervention group significantly improved at 3-6 months (-1.260, p = .040). At 6 months after surgery, the mean QuickDASH functional score was 18.54 (range 0.00-63.64, SD 17.4) in the intervention group and 28.70 ± 12 (range: 2.27-40.91) in the control group (p < .04). At 6 months after surgery, the mean VAS satisfaction score was 1.46 ± 1.95 (range: 0-4) in the intervention group and 2.48 ± 1.02 (range: 0-4) in the control group (p < .03).


      The Centella asiatica cream applied to the wrist after CTR surgery was found to be beneficial in preventing scar tenderness in the thenar and hypothenar regions of the hand.



      CTS (carpal tunnel syndrome), CTR (carpal tunnel release), VSS (Vancouver Scar Scale), QuickDASH (Quick Disabilities of Arm Shoulder and Hand functional score), VAS (Visual Analogue Scale)
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