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Conflicts of interest: The author has no conflicts of interest.
Funding declaration: Dr McGee is currently funded by the National Institutes of Health's National Center for Advancing Translational Sciences (UL1TR002494, PI: Blazar, KL2TR002492, PI: Ingbar) and the National Heart Lung, Blood Institute (OT2HL16847-01, Parent: NYU). The content within this lecture is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health.