Journal of Hand Therapy
Volume 22, Issue 2 , Pages 109-114 , April 2009

The Pathophysiology of Focal Hand Dystonia

  • Peter T. Lin, MD

      Affiliations

    • Corresponding Author InformationCorrespondence and reprint requests to Peter T. Lin, MD, Human Motor Control Section, NINDS, 10 Center Drive, NIH Building 10, Room 7D37, Bethesda, MD 20892-1428
  • ,
  • Mark Hallett, MD

References 

  1. Lim VK, Altenmuller E, Bradshaw JL. Focal dystonia: current theories. Hum Mov Sci. 2001;20:875–914
  2. Hallett M. Pathophysiology of writer's cramp. Hum Mov Sci. 2006;25:454–463
  3. Cohen LG, Hallett M. Hand cramps: clinical features and electromyographic patterns in a focal dystonia. Neurology. 1988;38:1005–1012
  4. Nakashima K, Rothwell JC, Day BL, Thompson PD, Shannon K, Marsden CD. Reciprocal inhibition between forearm muscles in patients with writer's cramp and other occupational cramps, symptomatic hemidystonia and hemiparesis due to stroke. Brain. 1989;113:681–697
  5. Chen R, Wassermann E, Canos M, Hallett M. Impaired inhibition in writer's cramp during voluntary muscle activation. Neurology. 1997;49:1054–1059
  6. Sohn YH, Hallett M. Disturbed surround inhibition in focal hand dystonia. Ann Neurol. 2004;56:529–537
  7. Levy LM, Hallett M. Impaired brain GABA in focal dystonia. Ann Neurol. 2002;51:93–101
  8. Cimatti Z, Schwartz DP, Bourdain F, et al. Time-frequency analysis reveals decreased high-frequency oscillations in writer's cramp. Brain. 2007;130:198–205
  9. Dhaenens CM, Krystkowiak P, Douay X, et al. Clinical and genetic evaluation in a French population presenting with primary focal dystonia. Mov Disord. 2005;20:822–825
  10. Meunier S, Hallett M. Endophenotyping: a window to the pathophysiology of dystonia. Neurology. 2007;65:792–793
  11. Meunier S, Garnero L, Ducorps A, et al. Human brain mapping in dystonia reveals both endophenotypic traits and adaptive reorganization. Ann Neurol. 2001;50:521–527
  12. Walsh R, O'Dwyer JP, Sheikh IH, O'Riordan S, Lynch T, Hutchinson M. Sporadic adult onset dystonia: sensory abnormalities as an endophenotype in unaffected relatives. J Neurol Neurosurg Psychiatry. 2007;78:980–983
  13. Byl N, Merzenich MM, Jenkins WM. A primate genesis model of focal dystonia and repetitive strain injury: I. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys. Neurology. 1996;47:508–520
  14. Leijnse JN, Hallett M. Etiological musculo-skeletal factor in focal dystonia in a musician's hand: a case study of the right hand of a guitarist. Mov Disord. 2007;22:1803–1808
  15. Espay AJ, Morgante F, Purzner J, Gunraj CA, Lang AE, Chen R. Cortical and spinal abnormalities in psychogenic dystonia. Ann Neurol. 2006;59:825–834
  16. Hamano T, Kaji R, Katayama M, et al. Abnormal contingent negative variation in writer's cramp. Clin Neurophysiol. 1999;1130:508–515
  17. Toro C, Deuschl G, Hallett M. Movement-related electroencephalographic desynchronization in patients with hand cramps: evidence for motor cortical involvement in focal dystonia. Ann Neurol. 2001;47:456–461
  18. Ibanez V, Sadato N, Karp B, Deiber MP, Hallett M. Deficient activation of the motor cortical network in patients with writer's cramp. Neurology. 1999;53:96–105
  19. Stinear CM, Byblow WD. Impaired modulation of intracortical inhibition in focal hand dystonia. Cereb Cortex. 2004;14:555–561
  20. Ghika J, Regli F, Growdon JH. Sensory symptoms in cranial dystonia: a potential role in the etiology?. J Neurol Sci. 1993;116:142–147
  21. Martino D, Defazio G, Alessio G. Relationship between eye symptoms and blepharospasm: a multicenter case-control study. Mov Disord. 2005;20:1564–1570
  22. Bara-Jimenez W, Catalan MJ, Hallett M, Gerloff C. Abnormal somatosensory homunculus in dystonia of the hand. Ann Neurol. 1998;44:828–831
  23. Elbert T, Candia V, Altenmuller E, et al. Alteration of digital representations in somatosensory cortex in focal hand dystonia. Neuroreport. 1998;9:3571–3575
  24. Bara-Jimenez W, Shelton P, Hallett M. Spatial discrimination is abnormal in focal hand dystonia. Neurology. 2000;55:1869–1873
  25. Tamura Y, Matsuhashi M, Lin P, et al. Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia. Mov Disord. 2008;23:558–565
  26. Molloy FM, Carr TD, Zeuner KE, Dambrosia JM, Hallett M. Abnormalities of spatial discrimination in focal and generalized dystonia. Brain. 2003;126:2175–2182
  27. Kaji R, Rothwell JC, Katayama M, et al. Tonic vibration reflex and muscle afferent block in writer's cramp. Ann Neurol. 1995;38:155–162
  28. Zeuner KE, Bara-Jimenez W, Noguchi PS, Goldstein SR, Dambrosia JM, Hallett M. Sensory training for patients with focal hand dystonia. Ann Neurol. 2002;51:593–598
  29. Tinazzi M, Rosso T, Fiaschi A. Role of the somatosensory system in primary dystonia. Mov Disord. 2003;18:605–622
  30. Hallett M. Is dystonia a sensory disorder?. Ann Neurol. 1995;38:139–140
  31. Murase N, Kaji R, Shimazu H, et al. Abnormal premovement gating of somatosensory input in writer's cramp. Brain. 2000;123:1813–1829
  32. Tamburin S, Manganotti P, Marzi CA, Fiaschi A, Zanette G. Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients. Brain. 2002;125:2719–2730
  33. Quartarone A, Bagnato S, Rizzo V, et al. Abnormal associative plasticity of the human motor cortex in writer's cramp. Brain. 2003;126:2586–2596
  34. Quartarone A, Rizzo V, Bagnato S, et al. Homeostatic-like plasticity of the primary motor hand area is impaired in focal hand dystonia. Brain. 2005;128:1943–1950
  35. Weise D, Schramm A, Stefan K, et al. The two sides of associative plasticity in writer's cramp. Brain. 2006;129:2709–2721
  36. Quartarone A, Morgante F, Sant'angelo A, et al. Abnormal plasticity of sensorimotor circuits extends beyond the affected body part in focal dystonia. J Neurol Neurosurg Psychiatry. 2008;79:985–990
  37. Candia V, Schafer T, Taub E, et al. Sensory motor retuning: a behavioral treatment for focal hand dystonia of pianists and guitarists. Arch Phys Med Rehabil. 2002;83:1342–1348
  38. Zeuner KE, Molloy FM. Abnormal reorganization in focal hand dystonia—sensory and motor training programs to retrain cortical function. NeuroRehabilitation. 2008;23:43–53
  39. Zeuner KE, Shill HA, Sohn YH, et al. Motor training as treatment in focal hand dystonia. Mov Disord. 2005;20:335–341

PII: S0894-1130(08)00179-8

doi: 10.1016/j.jht.2008.10.008

Journal of Hand Therapy
Volume 22, Issue 2 , Pages 109-114 , April 2009