Journal of Hand Therapy
Volume 18, Issue 2 , Pages 259-269, April 2005

Pathomechanics of Peripheral Nerve Loading:

Evidence in Carpal Tunnel Syndrome

  • Peter J. Keir, PhD

      Affiliations

    • Corresponding Author InformationCorrespondence and reprint requests to Peter J. Keir, PhD, School of Kinesiology and Health Science, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada

School of Kinesiology and Health Science, York University Toronto, Ontario, Canada

Ergonomics Program, Department of Medicine, University of California, San Francisco, San Francisco, California

Abstract 

Peripheral nerve injury is a common occurrence, with carpal tunnel syndrome (CTS) receiving the most attention. Nerve dysfunction associated with compression syndromes results from an interruption or localized interference of microvascular function due to structural changes in the nerves or surrounding tissues. This article reviews the physiologic, pathophysiologic, and histologic effects of compressing peripheral nerves in animal models, and then examines the evidence for similar processes in humans using CTS as a model.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 10.00 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0894-1130(05)00041-4

doi:10.1197/j.jht.2005.02.001

Journal of Hand Therapy
Volume 18, Issue 2 , Pages 259-269, April 2005

Article Tools

* Image Usage & Resolution