Journal of Hand Therapy
Volume 18, Issue 2 , Pages 87-92 , April 2005

The Use of Growth Factors on Tendon Injuries

  • Vishal Mehta, MD

      Affiliations

    • Corresponding Author InformationCorrespondence and reprint requests to Vishal Mehta, MD, Department of Surgery, Section of Orthopaedic Surgery, The University of Chicago Hospitals, MC 3079, Chicago, IL 60637
    • ,
  • Daniel Mass, MD

References 

  1. McGrath MH. Peptide growth factors and wound healing. Clin Plast Surg. 1990;17:421–432
  2. Conover CA, Rosenfeld RG, Hintz RL. Hormonal control of the replication of human fetal fibroblasts: role of somatomedin C/insulin-like growth factor I. J Cell Physiol. 1986;128:47–54
  3. Stein LE. Effects of serum, fibroblast growth factor, and platelet-derived growth factor on explants of rat tail tendon: a morphological study. Acta Anat (Basel). 1985;123:247–252
  4. Abrahamsson SO, Lundborg G, Lohmander LS. Long-term explant culture of rabbit flexor tendon: effects of recombinant human insulin-like growth factor-I and serum on matrix metabolism. J Orthop Res. 1991;9:503–515
  5. Abrahamsson SO, Lundborg G, Lohmander LS. Recombinant human insulin-like growth factor-I stimulates in vitro matrix synthesis and cell proliferation in rabbit flexor tendon. J Orthop Res. 1991;9:495–502
  6. Abrahamsson SO. Similar effects of recombinant human insulin-like growth factor-I and II on cellular activities in flexor tendons of young rabbits: experimental studies in vitro. J Orthop Res. 1997;15:256–262
  7. Banes AJ, Tsuzaki M, Hu P, et al. PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. J Biomech. 1995;28:1505–1513
  8. Duffy FJ, Seiler JG, Gelberman RH, et al. Growth factors and canine flexor tendon healing: initial studies in uninjured and repair models. J Hand Surg [Am]. 1995;20:645–649
  9. Chang J, Most D, Thunder R, et al. Molecular studies in flexor tendon wound healing: the role of basic fibroblast growth factor gene expression. J Hand Surg [Am]. 1998;23:1052–1058
  10. Rohrich RJ, Trott SA, Love M, et al. Mersilene suture as a vehicle for delivery of growth factors in tendon repair. Plast Reconstr Surg. 1999;104:1713–1717
  11. Chan BP, Fu S, Qin L, et al. Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: a rat patellar tendon model. Acta Orthop Scand. 2000;71:513–518
  12. Nakamura N, Horibe S, Matsumoto N, et al. Transient introduction of a foreign gene into healing rat patellar ligament. J Clin Invest. 1996;97:226–231
  13. Kurtz CA, Loebig TG, Anderson DD, et al. Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model. Am J Sports Med. 1999;27:363–369
  14. Storm EE, Huynh TV, Copeland NG, et al. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature. 1994;368:639–643
  15. Chang SC, Hoang B, Thomas JT, et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem. 1994;269:28227–28234
  16. Wolfman NM, Hattersley G, Cox K, et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest. 1997;100:321–330
  17. Forslund C, Rueger D, Aspenberg P. A comparative dose-response study of cartilage-derived morphogenetic protein (CDMP)-1, -2 and -3 for tendon healing in rats. J Orthop Res. 2003;21:617–621
  18. Lou J, Tu Y, Burns M, et al. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res. 2001;19:1199–1202
  19. Forslund C, Aspenberg P. Tendon healing stimulated by injected CDMP-2. Med Sci Sports Exerc. 2001;33:685–687
  20. Forslund C, Aspenberg P. Improved healing of transected rabbit Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2. Am J Sports Med. 2003;31:555–559
  21. Aspenberg P, Forslund C. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand. 1999;70:51–54
  22. Chang J, Most D, Stelnicki E, et al. Gene expression of transforming growth factor beta-1 in rabbit zone II flexor tendon wound healing: evidence for dual mechanisms of repair. Plast Reconstr Surg. 1997;100:937–944
  23. Chang J, Thunder R, Most D, et al. Studies in flexor tendon wound healing: neutralizing antibody to TGF-beta1 increases postoperative range of motion. Plast Reconstr Surg. 2000;105:148–155
  24. Manske PR, Gelberman RH, Lesker PA. Flexor tendon healing. Hand Clin. 1985;1:25–34
  25. Gelberman RH, Vandeberg JS, Manske PR, Akeson WH. The early stages of flexor tendon healing: a morphologic study of the first fourteen days. J Hand Surg [Am]. 1985;10(6 Pt 1):776–784
  26. Lou J, Manske PR, Aoki M, et al. Adenovirus-mediated gene transfer into tendon and tendon sheath. J Orthop Res. 1996;14:513–517
  27. Dai Q, Manfield L, Wang Y, et al. Adenovirus-mediated gene transfer to healing tendon: enhanced efficiency using a gelatin sponge. J Orthop Res. 2003;21:604–609
  28. Goomer RS, Maris TM, Gelberman R, et al. Nonviral in vivo gene therapy for tissue engineering of articular cartilage and tendon repair. Clin Orthop. 2000;379(S):189–200
  29. Newman KD, Dunn PF, Owens JW, et al. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest. 1995;96:2955–2965
  30. Worgall S, Wolff G, Falck-Pedersen E, et al. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther. 1997;8:37–44
  31. Lawrence MS, Foellmer HG, Elsworth JD, et al. Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus. Gene Ther. 1999;6:1368–1379
  32. Liu Q, Muruve DA. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther. 2003;10:935–940
  33. Nelson D., Weiss R. Penn researchers sued in gene therapy death: teen's parents also name ethicist as defendant. Washington Post. 2000;Sep 19:A03

PII: S0894-1130(05)00039-6

doi: 10.1197/j.jht.2005.01.012

Journal of Hand Therapy
Volume 18, Issue 2 , Pages 87-92 , April 2005

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